Ishihara S, Fukuda R, Moriyama N, Ishimura N, Kaji T, Kushiyama Y, Amano K, Hirakawa K, Amano Y, Adachi K, Ashizawa N, Fukumoto S
Second Dept. of Internal Medicine, Shimane Medical University, Japan.
Scand J Gastroenterol. 1997 May;32(5):460-4. doi: 10.3109/00365529709025081.
Glicentin is an intestinal polypeptide hormone which seems to promote intestinal metaplasia (IM) in the gastric mucosa. The aim of this study was to clarify whether Helicobacter pylori infection accelerates glicentin gene expression.
Glicentin mRNA was investigated by reverse-transcription polymerase chain reaction using gastric biopsies from 47 patients examined endoscopically and denying IM.
IM was observed in 18 (38.3%) cases histologically, but not in the other 29 (62.7%). Glicentin mRNA was significantly correlated with histological IM (P < 0.01) and was positively correlated with H. pylori infection (P < 0.05).
Our results indicate that H. pylori infection is associated with the induction of glicentin in the gastric mucosa, thus supporting the hypothesis that H. pylori infection accelerates IM of the stomach.
胃泌酸调节素是一种肠道多肽激素，似乎可促进胃黏膜肠化生（IM）。本研究的目的是阐明幽门螺杆菌感染是否会加速胃泌酸调节素基因表达。
采用逆转录聚合酶链反应，对47例经内镜检查且否认有肠化生的患者的胃活检组织进行胃泌酸调节素mRNA检测。
组织学检查发现18例（38.3%）有肠化生，其余29例（62.7%）未发现。胃泌酸调节素mRNA与组织学肠化生显著相关（P < 0.01），与幽门螺杆菌感染呈正相关（P < 0.05）。
我们的结果表明，幽门螺杆菌感染与胃黏膜中胃泌酸调节素的诱导有关，从而支持幽门螺杆菌感染加速胃肠化生这一假说。
