Sato H, Yamaguchi M, Shibasaki T, Ishii T, Bannai S
Department of Biochemistry, Institute of Basic Medical Sciences, University of Tsukuba, Ibaraki, Japan.
Biochem Pharmacol. 1995 May 17;49(10):1453-7. doi: 10.1016/0006-2952(95)00033-v.
Gold sodium thiomalate and auranofin, anti-rheumatic gold-containing compounds, induced some stress proteins in cultured mouse peritoneal macrophages. The enhanced synthesis of two proteins, heme oxygenase (a 34-kDa protein) and a 23-kDa protein, was particularly prominent. The 23-kDa protein induced by the gold compounds was identical to that found in macrophages exposed to oxidative stress and was suggested to have antioxidant activity. Intraperitoneal injection of gold sodium thiomalate and oral administration of auranofin to mice induced enhanced synthesis of these proteins in peritoneal macrophages analyzed ex vivo. These data suggest that increased synthesis of these proteins may have a role in mediating the pharmacologic effect of these agents.
硫代苹果酸金钠和金诺芬，两种含抗风湿金的化合物，可在培养的小鼠腹腔巨噬细胞中诱导产生一些应激蛋白。两种蛋白——血红素加氧酶（一种34 kDa的蛋白）和一种23 kDa的蛋白——的合成增强尤为显著。金化合物诱导产生的23 kDa蛋白与暴露于氧化应激的巨噬细胞中发现的蛋白相同，并且被认为具有抗氧化活性。对小鼠腹腔注射硫代苹果酸金钠及口服金诺芬，可在体外分析的腹腔巨噬细胞中诱导这些蛋白的合成增强。这些数据表明，这些蛋白合成的增加可能在介导这些药物的药理作用中发挥作用。
