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Effect of coexisting cells on the NGF-inducing neurite growth from PC12h-R.

作者信息

Matsuoka H, Kazuno Y, Horie T, Homma T, Nemoto Y

机构信息

Department of Biotechnology, Faculty of Technology, Tokyo University of Agriculture and Technology, Japan.

出版信息

Cytotechnology. 1993;11(1):59-65. doi: 10.1007/BF00749058.

DOI:10.1007/BF00749058
PMID:7763637
Abstract

Possible roles of coexisting cells in inducing neurite growth from a nerve cell were studied. Nerve growth factor (NGF)-inducing neurite growth from PC12h-R (a cell line derived from cultured nerve cells) was investigated at various cell densities. At the cell density 10(2)-10(4) cells/ml neurites appeared even without NGF. In contrast, no neurite appeared without NGF in single cell culture. The neurite growth observed in plural cell culture without NGF was only partially inhibited by antibody to NGF receptor (Ab-NGFR). However, the effect of the used medium alone was mostly inhibited by Ab-NGFR. These results suggest that the neurite inducing potency of coexisting cells is via different sites than the NGF receptor.

摘要

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本文引用的文献

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