Falzano L, Fiorentini C, Boquet P, Donelli G
Department of Ultrastructures, Istituto Superiore di Sanità, Rome, Italy.
Cytotechnology. 1993;11 Suppl 1:S56-8.
The cytotoxic necrotizing factor type 1 (CNF1) from E. coli causes necrosis in rabbit skin and multinucleation in cultured cells. Cells exposed to CNF1 were characterized by changes in actin organization, mainly consisting in the presence of well-developed stress fibers and membrane ruffles. The interaction of CNF1 with the cell cytoskeleton probably promotes the cell spreading and interferes with the cytokinesis, leading to the formation of giant multinucleated cells.
大肠杆菌的细胞毒性坏死因子1（CNF1）可导致兔皮肤坏死以及培养细胞出现多核化现象。暴露于CNF1的细胞表现为肌动蛋白组织发生变化，主要特征是出现发育良好的应力纤维和膜皱褶。CNF1与细胞细胞骨架的相互作用可能会促进细胞铺展并干扰胞质分裂，从而导致形成巨大的多核细胞。
