Department of Ultrastructures, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161, Rome, Italy.
Cytotechnology. 1993 Jan;11(Suppl 1):S56-8. doi: 10.1007/BF00746055.
The cytotoxic necrotizing factor type 1 (CNF1) fromE. coli causes necrosis in rabbit skin and multinucleation in cultured cells. Cells exposed to CNF1 were characterized by changes in actin organization, mainly consisting in the presence of well-developed stress fibers and membrane ruffles. The interaction of CNF1 with the cell cytoskeleton probably promotes the cell spreading and interferes with the cytokinesis, leading to the formation of giant multinucleated cells.
大肠杆菌细胞毒素坏死因子 1（CNF1）可引起家兔皮肤坏死和培养细胞的多核化。用 CNF1 处理过的细胞的特征是肌动蛋白组织发生变化，主要表现为存在发育良好的应激纤维和膜皱褶。CNF1 与细胞细胞骨架的相互作用可能促进细胞铺展，并干扰胞质分裂，导致巨多核细胞的形成。
