Ahmed S G, Ahmed A el H, Omar N M, el-Gendy M A
Organic Pharmaceutical Chemistry Department, Faculty of Pharmacy, Assiut University, Egypt.
J Chem Technol Biotechnol. 1993;57(4):363-70. doi: 10.1002/jctb.280570411.
The pyrimido[1,2-alpha]benzimidazole derivatives compounds 1-8 were synthesized through cyclocondensation of 2-aminobenzimidazole with the appropriate benzsubstituted benzoylacetone by fusion at 150-170 degrees C for 5 h. Quaternary salts compounds 9-22 were obtained by quaternization of compounds 1-8 with dimethyl or diethyl sulfate and subsequent isolation as the relatively insoluble perchlorate salts. Assignment and confirmation of the structures of the newly synthesized compounds were based upon elemental microanalyses and other spectral evidence.
嘧啶并[1,2-α]苯并咪唑衍生物化合物1-8是通过2-氨基苯并咪唑与适当的苯取代苯甲酰丙酮在150-170℃下熔融5小时进行环缩合反应合成的。季铵盐化合物9-22是通过化合物1-8与硫酸二甲酯或硫酸二乙酯进行季铵化反应，随后分离得到相对不溶的高氯酸盐而制得。新合成化合物结构的确定和确认基于元素微量分析和其他光谱证据。
