Shaabani Ahmad, Rahmati Abbas, Naderi Soheila
Department of Chemistry, Shahid Beheshti University, PO Box 19396-4716, Tehran, Iran.
Bioorg Med Chem Lett. 2005 Dec 15;15(24):5553-7. doi: 10.1016/j.bmcl.2005.08.101. Epub 2005 Oct 19.
A novel one-pot three-component condensation reaction of an aldehyde, beta-ketoester and 2-aminobenzimidazole or 2-aminobenzothiazole in 1,1,3,3-N,N,N',N'-tetramethylguanidinium trifluoroacetate as an ionic liquid is described. During the course of this reaction 4H-pyrimido[2,1-b]benzimidazoles or 4H-pyrimido[2,1-b]benzothiazoles are formed in high yields at 100 degrees C. The ionic liquid can be recovered conveniently and reused efficiently.
描述了一种在1,1,3,3 - N,N,N',N'-四甲基胍三氟乙酸盐作为离子液体的条件下，醛、β-酮酯与2-氨基苯并咪唑或2-氨基苯并噻唑的新型一锅三组分缩合反应。在该反应过程中，4H-嘧啶并[2,1-b]苯并咪唑或4H-嘧啶并[2,1-b]苯并噻唑在100℃下以高产率生成。离子液体可方便地回收并高效重复使用。
