长叶番荔枝素、长叶番荔枝苷和巨大四氢呋喃酮，三种从长叶番荔枝（番荔枝科）中分离出的新型生物活性单四氢呋喃类番荔枝内酯。

Longifolicin, longicoricin, and gigantetroneninone, three novel bioactive mono-tetrahydrofuran annonaceous acetogenins from Asimina longifolia (Annonaceae).

作者信息

Ye Q, Alfonso D, Evert D, McLaughlin J L

机构信息

Department of Medicinal Chemistry and Pharmacognosy, School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette, IN 47907, USA.

出版信息

Bioorg Med Chem. 1996 Apr;4(4):537-45. doi: 10.1016/0968-0896(96)00039-9.

DOI:10.1016/0968-0896(96)00039-9

PMID:8735841

Abstract

Longifolicin (1), longicoricin (2) and (2,4-cis and trans)-gigantetroneninone (3), three novel bioactive mono-tetra-hydrofuran (THF) gamma-lactone acetogenins, were isolated from the leaves and twigs of Asimina longifolia (Annonaceae) by directing the fractionation with the brine shrimp lethality test (BST). The structures were elucidated based on spectroscopic and chemical methods. Compounds 1-3 showed selective and potent cytotoxicities to certain human tumor cell lines.

摘要

通过卤虫致死试验（BST）指导分馏，从长叶番荔枝（番荔枝科）的叶子和嫩枝中分离出了三种新型生物活性单四氢呋喃（THF）γ-内酯番荔枝内酯，即长叶番荔枝素（1）、长叶番荔枝苷（2）和（2,4-顺式和反式）-巨大四氢呋喃酮（3）。基于光谱和化学方法阐明了其结构。化合物1-3对某些人类肿瘤细胞系表现出选择性和强效的细胞毒性。