来自岷江百合和湖北百合鳞茎的甾体皂苷。

Steroidal saponins from the bulbs of Lilium regale and L. henryi.

作者信息

Mimaki Y, Sashida Y, Nakamura O, Nikaido T, Ohmoto T

机构信息

Tokyo College of Pharmacy, Japan.

出版信息

Phytochemistry. 1993 Jun;33(3):675-82. doi: 10.1016/0031-9422(93)85472-4.

DOI:10.1016/0031-9422(93)85472-4

PMID:7764061

Abstract

Two new and three known steroidal saponins were isolated from the fresh bulbs of Lilium regale and two known saponins from those of L. henryi. The structures of the new saponins were established by extensive spectral data, hydrolysis and chemical correlation as (25R)-27-O-[(S)-3-hydroxy-3-methylglutaroyl]-spirost-5 -ene-3 beta,27-diol 3-O-alpha-L-rhamnopyranosyl-(1-->2)-O-[beta-D-glucopyranosyl-(1-->3)]- beta-D-glucopyranoside and (25S)-spirost-5-ene-3 beta,17 alpha,27-triol 3-O-alpha-L-rhamnopyranosyl-(1-->2)-O-[beta-D-glucopyranosyl-(1-->2)-O- beta-D-glucopyranosyl-(1-->4)]-beta-D-glucopyranoside. Inhibitory activity of the saponins on cyclic AMP phosphodiesterase was evaluated.

摘要

从岷江百合的新鲜鳞茎中分离出两种新的甾体皂苷和三种已知的甾体皂苷，从湖北百合的新鲜鳞茎中分离出两种已知的甾体皂苷。通过广泛的光谱数据、水解和化学关联确定了新皂苷的结构，分别为(25R)-27-O-[(S)-3-羟基-3-甲基戊二酰基]-螺旋甾-5-烯-3β,27-二醇3-O-α-L-鼠李吡喃糖基-(1→2)-O-[β-D-吡喃葡萄糖基-(1→3)]-β-D-吡喃葡萄糖苷和(25S)-螺旋甾-5-烯-3β,17α,27-三醇3-O-α-L-鼠李吡喃糖基-(1→2)-O-[β-D-吡喃葡萄糖基-(1→2)-O-β-D-吡喃葡萄糖基-(1→4)]-β-D-吡喃葡萄糖苷。评估了这些皂苷对环磷酸腺苷磷酸二酯酶的抑制活性。