菝葜根茎中的甾体皂苷。

Steroidal saponins from the rhizomes of Smilax sieboldii.

作者信息

Kubo S, Mimaki Y, Sashida Y, Nikaido T, Ohmoto T

机构信息

Tokyo College of Pharmacy, Japan.

出版信息

Phytochemistry. 1992 Jul;31(7):2445-50. doi: 10.1016/0031-9422(92)83296-b.

DOI:10.1016/0031-9422(92)83296-b

PMID:1369386

Abstract

Six new steroidal saponins were isolated from the rhizomes of Smilax sieboldii. Their structures were determined by spectroscopic analysis and hydrolysis to be 3 beta-hydroxy-(25R)-5 alpha-spirostan-6-one (laxogenin) 3-O-beta-D-glucopyranosyl-(1----4)-O-[alpha-L-arabinopyranosyl-(1- ---6)]-beta-D-glucopyranoside, laxogenin 3-O-alpha-L-arabinopyranosyl-(1----6)-beta-D-glucopyranoside, 3 beta,27-dihydroxy-(25S)-5 alpha-spirostan-6-one 3-O-beta-D-glucopyranosyl-(1----4)-O-[alpha-L-arabinopyranosyl-(1- ---6)]- beta-D-glucopyranoside, 26-O-beta-D-glucopyranosyl-3 beta,22 xi,26-trihydroxy-(25R)-5 alpha-furostan-6-one 3-O-alpha-L-arabinopyranosyl-(1----6)-beta-D-glucopyranoside, 26-O-beta-D-glucopyranosyl-3 beta,22 xi,26-trihydroxy-(25R)-5 alpha-furostan-6- one 3-O-beta-D-glucopyranosyl-(1----4)-O-[alpha-L-arabinopyranosyl-(1- ---6)]- beta-D-glucopyranoside and (25R)-5 alpha-spirostan-3 beta-ol (tigogenin) 3-O-beta-D-glucopyranosyl-(1----4)-O-[alpha-L-arabinopyranosyl- (1----6)]-beta-D-glucopyranoside. The inhibition of cAMP phosphodiesterase by the saponins was evaluated.

摘要

从华东菝葜根茎中分离出6种新的甾体皂苷。通过光谱分析和水解确定它们的结构分别为3β-羟基-(25R)-5α-螺旋甾烷-6-酮（拉肖皂苷元）3-O-β-D-吡喃葡萄糖基-(1→4)-O-[α-L-吡喃阿拉伯糖基-(1→6)]-β-D-吡喃葡萄糖苷、拉肖皂苷元3-O-α-L-吡喃阿拉伯糖基-(1→6)-β-D-吡喃葡萄糖苷、3β,27-二羟基-(25S)-5α-螺旋甾烷-6-酮3-O-β-D-吡喃葡萄糖基-(1→4)-O-[α-L-吡喃阿拉伯糖基-(1→6)]-β-D-吡喃葡萄糖苷、26-O-β-D-吡喃葡萄糖基-3β,22ξ,26-三羟基-(25R)-5α-呋甾烷-6-酮3-O-α-L-吡喃阿拉伯糖基-(1→6)-β-D-吡喃葡萄糖苷、26-O-β-D-吡喃葡萄糖基-3β,22ξ,26-三羟基-(25R)-5α-呋甾烷-6-酮3-O-β-D-吡喃葡萄糖基-(1→4)-O-[α-L-吡喃阿拉伯糖基-(1→6)]-β-D-吡喃葡萄糖苷和(25R)-5α-螺旋甾烷-3β-醇（替告皂苷元）3-O-β-D-吡喃葡萄糖基-(1→4)-O-[α-L-吡喃阿拉伯糖基-(1→6)]-β-D-吡喃葡萄糖苷。对这些皂苷抑制环磷酸腺苷磷酸二酯酶的活性进行了评估。