来自麝香百合鳞茎的甾体皂苷及其抗肿瘤促进活性。
Steroidal saponins from the bulbs of Lilium longiflorum and their antitumour-promoter activity.
作者信息
Mimaki Y, Nakamura O, Sashida Y, Satomi Y, Nishino A, Nishino H
机构信息
Tokyo College of Pharmacy, Japan.
出版信息
Phytochemistry. 1994 Sep;37(1):227-32. doi: 10.1016/0031-9422(94)85030-5.
Two new spirostanol saponins and two new furostanol saponins were isolated from the fresh bulbs of Lilium longiflorum together with several known saponins. The structures of new compounds were determined to be (25S)-spirost-5-ene-3 beta, 27-diol 3-O-(O-alpha-L-rhamnopyranosyl-(1-->2)-O- [alpha-L-arabinopyranosyl-(1-->3)]-beta-D-glucopyranoside), (25R)-27-O-[(S)-3-hydroxy-3-methylglutaryl]-spirost-5-ene-3 beta,27 diol 3-O-(O-alpha-L-rhamnopyranosyl-(1-->2)-O-[alpha-L-arabinopyranosyl -(1-->3)] - beta-D-glucopyranoside), 22-O-methyl-26-O-beta-D-glucopyranosyl-(25R)-furost-5-ene-3 beta,22 xi, 26-triol 3-O-(O-alpha-L-rhamnopyranosyl-(1-->2)-O-[alpha-L- arabinopyranosyl-(1-->3)]-beta-D-glucopyranoside) and 22-O-methyl-26-O-beta-D-glucopyranosyl-(25R)-furost-5-ene-3 beta, zeta, 26-triol 3-O-(O-alpha-L-rhamnopyranosyl-(1 --> 2)- O-[beta-D-xylopyranosyl-(1 --> 3)]-beta-D-glucopyranoside). The isolated saponins and their derivatives were examined for inhibitory activity on 12-O-tetradecanoylphorbol-13-acetate (TPA)-stimulated 32P-incorporation into phospholipids of HeLa cells as the primary screening test to find new antitumour-promoter compounds.
从麝香百合的新鲜鳞茎中分离出两种新的螺旋甾烷醇皂苷和两种新的呋甾烷醇皂苷以及几种已知的皂苷。新化合物的结构被确定为(25S)-螺旋甾-5-烯-3β,27-二醇3-O-(O-α-L-鼠李吡喃糖基-(1→2)-O-[α-L-阿拉伯吡喃糖基-(1→3)]-β-D-葡萄糖吡喃糖苷)、(25R)-27-O-[(S)-3-羟基-3-甲基戊二酰基]-螺旋甾-5-烯-3β,27-二醇3-O-(O-α-L-鼠李吡喃糖基-(1→2)-O-[α-L-阿拉伯吡喃糖基-(1→3)]-β-D-葡萄糖吡喃糖苷)、22-O-甲基-26-O-β-D-葡萄糖吡喃糖基-(25R)-呋甾-5-烯-3β,22ξ,26-三醇3-O-(O-α-L-鼠李吡喃糖基-(1→2)-O-[α-L-阿拉伯吡喃糖基-(1→3)]-β-D-葡萄糖吡喃糖苷)和22-O-甲基-26-O-β-D-葡萄糖吡喃糖基-(25R)-呋甾-5-烯-3β,ζ,26-三醇3-O-(O-α-L-鼠李吡喃糖基-(1→2)-O-[β-D-木糖吡喃糖基-(1→3)]-β-D-葡萄糖吡喃糖苷)。对分离得到的皂苷及其衍生物进行了抑制12-O-十四酰佛波醇-13-乙酸酯(TPA)刺激的32P掺入HeLa细胞磷脂的活性检测，作为寻找新的抗肿瘤促进剂化合物的初步筛选试验。
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