来自巨型雪滴花鳞茎的羊毛甾醇和27-降羊毛甾醇低聚糖。

Lanosterol and 27-norlanosterol oligosaccharides from the bulbs of Chionodoxa gigantea.

作者信息

Mimaki Y, Kubo S, Kinoshita Y, Sashida Y, Song L G, Nikaido T, Ohmoto T

机构信息

Tokyo College of Pharmacy, Japan.

出版信息

Phytochemistry. 1993 Oct;34(3):791-7. doi: 10.1016/0031-9422(93)85361-t.

DOI:10.1016/0031-9422(93)85361-t

PMID:7764152

Abstract

New lanosterol and 27-norlanosterol oligosaccharides were found in the bulbs of Chionodoxa gigantea. Their structures were established mainly by extensive 2D NMR analysis as well as by comparison with spectral data of known compounds. The inhibition of cyclic AMP phosphodiesterase by the lanosterol derivatives was assayed as the primary screening test to find new medicinal materials.

摘要

在巨型雪滴花的球茎中发现了新的羊毛甾醇和27-去甲羊毛甾醇低聚糖。它们的结构主要通过广泛的二维核磁共振分析以及与已知化合物的光谱数据进行比较来确定。作为寻找新药材的初步筛选试验，测定了羊毛甾醇衍生物对环磷酸腺苷磷酸二酯酶的抑制作用。