绵枣儿亚科植物中的羊毛甾醇低聚糖及其抗肿瘤促进活性。

Lanosterol oligosaccharides from the plants of the subfamily Scilloideae and their antitumor-promoter activity.

作者信息

Mimaki Y, Nishino H, Ori K, Kuroda M, Matsui T, Sashida Y

机构信息

Tokyo College of Pharmacy, Japan.

出版信息

Chem Pharm Bull (Tokyo). 1994 Feb;42(2):327-32. doi: 10.1248/cpb.42.327.

DOI:10.1248/cpb.42.327

PMID:8149459

Abstract

Phytochemical studies of the bulbs of Scilla peruviana, Eucomis bicolor, Chionodoxa gigantea and C. luciliae gave respectively two new and two known, four new and two known, three known, and one new and five known lanosterol oligosaccharides. The structures of the new compounds were determined from spectroscopic data. A total of 19 lanosterols, including previously isolated compounds, were examined for inhibitory activity on 12-O-tetradecanoylphorbol 13-acetate (TPA)-stimulated 32P incorporation into phospholipids of HeLa cells as the primary screening test to find new antitumor-promoter compounds.

摘要

对秘鲁绵枣儿、双色绵枣儿、巨型雪光花和露西雪光花的鳞茎进行植物化学研究，分别得到了两种新的和两种已知的、四种新的和两种已知的、三种已知的以及一种新的和五种已知的羊毛甾醇低聚糖。通过光谱数据确定了新化合物的结构。总共检测了19种羊毛甾醇（包括先前分离得到的化合物）对12 - O - 十四烷酰佛波醇13 - 乙酸酯（TPA）刺激的32P掺入HeLa细胞磷脂中的抑制活性，作为寻找新型抗肿瘤促进剂化合物的初步筛选试验。