尖锐毛壳菌产生毛壳菌素A和B，它们是法尼基蛋白转移酶的可逆抑制剂。
Chaetomella acutiseta produces chaetomellic acids A and B which are reversible inhibitors of farnesyl-protein transferase.
作者信息
Lingham R B, Silverman K C, Bills G F, Cascales C, Sanchez M, Jenkins R G, Gartner S E, Martin I, Diez M T, Peláez F
机构信息
Merck Research Laboratories, Rahway, NJ 07065.
出版信息
Appl Microbiol Biotechnol. 1993 Nov;40(2-3):370-4. doi: 10.1007/BF00170395.
Chaetomellic acids A and B, isolated from Chaetomella acutiseta, are specific inhibitors of farnesyl-protein transferase that do not inhibit geranylgeranyl transferase type 1 or squalene synthase. Chaetomellic acids A and B are reversible inhibitors, resemble farnesyl diphosphate and probably inhibit FPTase by substituting for farnesyl diphosphate. Chaetomellic acid production appears to be widespread within the genus Chaetomella.
从尖锐毛壳菌中分离得到的毛壳菌素A和B是法尼基蛋白转移酶的特异性抑制剂，它们不抑制1型香叶基香叶基转移酶或角鲨烯合酶。毛壳菌素A和B是可逆抑制剂，类似于法尼基二磷酸，可能通过取代法尼基二磷酸来抑制法尼基蛋白转移酶。毛壳菌素的产生似乎在毛壳菌属中广泛存在。
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