Schreurs J
Department of Pharmacology, G119, Chiron Corporation, Emeryville, California 94608-2916.
Curr Opin Biotechnol. 1993 Dec;4(6):727-33. doi: 10.1016/0958-1669(93)90057-4.
The immune system is poised like a fulcrum to respond quickly to challenge by infectious agents, but can produce excess inflammatory signals or excess suppressive signals when out of balance. During the past year, significant progress has been made in our understanding of how certain pathogens promote immune suppression and shift the balance from the host in their favor. Understanding the mechanisms that underlie excessive inflammatory responses or the suppressive effects of the micro-organism will aid in the development of new therapies.
免疫系统就像一个支点，随时准备迅速应对感染因子的挑战，但失衡时会产生过多的炎症信号或抑制信号。在过去一年里，我们对于某些病原体如何促进免疫抑制以及如何将平衡从宿主方转向有利于它们自身的方向有了重大进展。了解过度炎症反应或微生物抑制作用背后的机制将有助于开发新的治疗方法。
