Broughton A, Strong J E
Clin Chem. 1976 Jun;22(6):726-32.
Theapeutic monitoring of drugs has become of major importance and has stimulated development of new assay systems. Chemotherapeutic agents, many of which are toxic, have until recently been assayed by microbiological systems or other complex techniques that are impractical for a clinical laboratory. Radioimmunoassays have now been developed for some of these agents. We review the techniques for producing hapten protein conjugates and radiolabeling at specific sites on the drug molecule, and the use of these assays in clinical medicine and pharmacology.
药物的治疗监测已变得至关重要，并推动了新检测系统的发展。化疗药物中有许多是有毒的，直到最近，它们一直通过微生物系统或其他对临床实验室不实用的复杂技术进行检测。现在已经为其中一些药物开发了放射免疫测定法。我们综述了制备半抗原蛋白结合物和在药物分子特定部位进行放射性标记的技术，以及这些测定法在临床医学和药理学中的应用。
