产黄青霉在碳源受限分批发酵中青霉素的振荡形成。
Oscillatory penicillin formation in carbon-limited batch fermentations of Penicillium chrysogenum.
作者信息
Siegmund D
机构信息
Institut für Mikrobiologie, Universität Hannover, Germany.
出版信息
Appl Microbiol Biotechnol. 1994 Feb;40(6):888-91. doi: 10.1007/BF00173994.
Circadian oscillations of penicillin productivity with a period of 22 +/- 2 h have been observed in carbon-limited batch fermentations of Penicillium chrysogenum. The specific penicillin production rate oscillated with an amplitude of 20 to 100% of its mean value, depending on the growth rate of the active (respiring and producting) biomass. In spite of this, the penicillin concentration increased almost linearly if the optimum growth rate of the active biomass for maximum penicillin productivity was maintained using microprocessor control. This apparently inconsistent behaviour of the fungus is discussed on the basis of chaos theory.
在产黄青霉的碳限制分批发酵中，已观察到青霉素生产力的昼夜节律振荡，周期为22±2小时。青霉素的比生产速率振荡幅度为其平均值的20%至100%，这取决于活性（呼吸和产青霉素）生物量的生长速率。尽管如此，如果使用微处理器控制将活性生物量的最佳生长速率维持在最大青霉素生产力，青霉素浓度几乎呈线性增加。基于混沌理论对这种明显不一致的真菌行为进行了讨论。
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