肾脏感染中补体介导的免疫机制。II. 补体缺失的影响。

Complement-mediated immune mechanisms in renal infection. II. Effect of decomplementation.

作者信息

Miller T E, Phillips S, Simpson I J

出版信息

Clin Exp Immunol. 1978 Jul;33(1):115-21.

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1537524/

Abstract

Animals were depleted of complement using cobra venom factor and the influence of complement depletion on the course of renal infection was studied. Complement depletion markedly increased the susceptibility of renal tissue to a challenge with an E. coli strain sensitive to the bactericidal activity of normal serum, but did not influence the outcome of a challenge with a serum-resistant strain of E. coli. These observations are consistent with the hypothesis that complement-mediated host immune mechanisms do play a role in the biology of renal infection and are an important component of the host's immune response in pyelonephritis.

摘要

使用眼镜蛇毒因子去除动物体内的补体，并研究补体去除对肾脏感染病程的影响。补体去除显著增加了肾脏组织对一种对正常血清杀菌活性敏感的大肠杆菌菌株攻击的易感性，但不影响对血清抗性大肠杆菌菌株攻击的结果。这些观察结果与以下假设一致，即补体介导的宿主免疫机制在肾脏感染生物学中确实发挥作用，并且是肾盂肾炎中宿主免疫反应的重要组成部分。

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