抗原诱导的抗体构象变化：结构预测与设计面临的一个问题。
Antigen-induced conformational changes in antibodies: a problem for structural prediction and design.
作者信息
Stanfield R L, Wilson I A
机构信息
Department of Molecular Biology, Scripps Research Institute, La Jolla, CA 92037.
出版信息
Trends Biotechnol. 1994 Jul;12(7):275-9. doi: 10.1016/0167-7799(94)90139-2.
PMID:7765075
Abstract
Recent work has shown that large conformational changes in antibodies can accompany antigen binding. These structural changes can alter dramatically the size, shape and charge distribution in the antigen-binding pocket, and may present problems for accurate modeling of antibody structures.
摘要
近期研究表明，抗体与抗原结合时会伴随较大的构象变化。这些结构变化会显著改变抗原结合口袋的大小、形状和电荷分布，可能给抗体结构的精确建模带来问题。
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