Mayeno A N, Gleich G J
Allergic Diseases Research Laboratory, Mayo Clinic, Rochester, MN 55905.
Trends Biotechnol. 1994 Sep;12(9):346-52. doi: 10.1016/0167-7799(94)90035-3.
An epidemic of a new disease, termed eosinophilia-myalgia syndrome, occurred in the USA in 1989. This syndrome was linked to the consumption of L-tryptophan manufactured by a single company utilizing a fermentation process. All the findings indicate that the illness was probably triggered by an impurity formed when the manufacturing conditions were modified. This outbreak highlights the need for close monitoring of the chemical purity of biotechnology-derived products, and for rigorous testing of such products following any significant changes to the manufacturing process.
1989年，美国爆发了一种名为嗜酸性粒细胞增多性肌痛综合征的新疾病。该综合征与一家公司采用发酵工艺生产的L-色氨酸的消费有关。所有研究结果表明，这种疾病可能是由生产条件改变时形成的一种杂质引发的。此次疫情凸显了密切监测生物技术衍生产品化学纯度的必要性，以及在生产工艺发生任何重大变化后对这类产品进行严格检测的必要性。
