Wu T S, Ou L F, Teng C M
Department of Chemistry, National Cheng Kung University, TaiNan, Taiwan, R.O.C.
Phytochemistry. 1994 Jul;36(4):1063-8. doi: 10.1016/s0031-9422(00)90492-8.
Fourteen aristolochic acid derivatives: ariskanins A-E, 3-hydroxy-4-methoxy-10-nitrophenanthrene-1-carboxylic acid methyl ester, aristolochic acid-II methyl ester, aristolochic acid-IV methyl ester, aristolochic acid-C, -I, -II, -III, -IV, -IVa; nine aristolactam alkaloids: aristolactam, aristolactam-AII, -BIII, -AIII, -III, cepharanone-A, 9-methoxy-aristolactam-I, aristolactam-N-beta-D-glucoside and aristolactam-C-N-beta-D-glucoside; a 4,5-dioxoaporphine alkaloid: cepharadione-A, together with 12 other compounds: methyl-p-coumarate, N-trans-feruloyltyramine, N-cis-feruloyltyramine, methyl vanillate, methyl paraben, allantoin, an octadecyl- and eicosyl ferulate mixture, cis- and trans-p-coumaric acid, N-p-coumaroyltyramine, N-p-cis-coumaroyltyramine, methyl ferulate and isorhamnetin-3-O-rutinoside were isolated and characterized from the fresh root and stem of Aristolochia kankauensis. Their structures were elucidated by spectral and chemical methods. Among them, ariskanins-A-E and N-p-cis-coumaroyltyramine are reported for the first time from a natural source. The cytotoxicity and antiplatelet activity of the compounds isolated are also discussed.
从管南马兜铃的新鲜根和茎中分离并鉴定出14种马兜铃酸衍生物：阿里坎宁A - E、3 - 羟基 - 4 - 甲氧基 - 10 - 硝基菲 - 1 - 羧酸甲酯、马兜铃酸 - II甲酯、马兜铃酸 - IV甲酯、马兜铃酸 - C、 - I、 - II、 - III、 - IV、 - IVa；9种马兜铃内酰胺生物碱：马兜铃内酰胺、马兜铃内酰胺 - AII、 - BIII、 - AIII、 - III、千金藤酮 - A、9 - 甲氧基 - 马兜铃内酰胺 - I、马兜铃内酰胺 - N - β - D - 葡萄糖苷和马兜铃内酰胺 - C - N - β - D - 葡萄糖苷；1种4,5 - 二氧代阿朴啡生物碱：头花千金藤二酮 - A，以及其他12种化合物：对香豆酸甲酯、N - 反式 - 阿魏酰酪胺、N - 顺式 - 阿魏酰酪胺、香草酸甲酯、对羟基苯甲酸甲酯、尿囊素、十八烷基和二十烷基阿魏酸混合物、顺式和反式对香豆酸、N - 对香豆酰酪胺、N - 对顺式香豆酰酪胺、阿魏酸甲酯和异鼠李素 - 3 - O - 芸香糖苷。通过光谱和化学方法阐明了它们的结构。其中，阿里坎宁A - E和N - 对顺式香豆酰酪胺首次从天然来源报道。还讨论了所分离化合物的细胞毒性和抗血小板活性。
