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约旦野生马兜铃中新型马兜铃酸及其他化学成分

New aristolochic acid and other chemical constituents of Aristolochia maurorum growing wild in Jordan.

作者信息

Al-Barham Mohammed B, Al-Jaber Hala I, Al-Qudah Mahmoud A, Abu Zarga Musa H

机构信息

a Faculty of Science, Department of Chemistry , The University of Jordan , Amman , Jordan.

b Faculty of Engineering Technology, Department of Physics and Basic Sciences , Al-Balqa Applied University , Amman , Jordan.

出版信息

Nat Prod Res. 2017 Feb;31(3):245-252. doi: 10.1080/14786419.2016.1226833. Epub 2016 Sep 15.

DOI:10.1080/14786419.2016.1226833
PMID:27628622
Abstract

Investigation of the chemical constituents of Aristolochia maurorum growing wild in Jordan resulted in the isolation and characterisation of one new compound in addition to 19 known compounds. The new compound was identified as aristolochic acid II alanine amide (14). The other known compounds were the following: palmitic acid (1), β-sitosterol (2), E-ethyl-p-coumarate (3), Z-ethyl-p-coumarate (4), aristolochic acid IV methyl ester (5), aristolactam I (6), loliolide (7), (+)-dehydrovomifoliol (8), glycerol-1-palmitate (9), aristolochic acid I (10), E-p-coumaric acid (11), E-N-coumaroyltyramine (12), β-sitosteryl glucoside (13), aristolochic acid IV (15), aristolochic acid III (16), esculetin (17), uracil (18), shepherdine (19) and adenosine (20). The isolated compounds were characterised by different spectroscopic methods including NMR (1D and 2D), UV, IR and HRESIMS.

摘要

对约旦野生马兜铃化学成分的研究,除了19种已知化合物外,还分离并鉴定了一种新化合物。该新化合物被鉴定为马兜铃酸II丙氨酸酰胺(14)。其他已知化合物如下:棕榈酸(1)、β-谷甾醇(2)、E-乙基对香豆酸酯(3)、Z-乙基对香豆酸酯(4)、马兜铃酸IV甲酯(5)、马兜铃内酰胺I(6)、黑麦草内酯(7)、(+)-脱氢催吐萝芙木醇(8)、甘油-1-棕榈酸酯(9)、马兜铃酸I(10)、E-对香豆酸(11)、E-N-香豆酰酪胺(12)、β-谷甾醇葡萄糖苷(13)、马兜铃酸IV(15)、马兜铃酸III(16)、七叶亭(17)、尿嘧啶(18)、异紫堇杷明(19)和腺苷(20)。通过包括NMR(一维和二维)、UV、IR和HRESIMS在内的不同光谱方法对分离出的化合物进行了表征。

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