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氯化镍对脾脏中初次抗体产生的影响。

Effect of nickel chloride on primary antibody production in the spleen.

作者信息

Graham J A, Gardner D E, Miller F J, Daniels M J, Coffin D L

出版信息

Environ Health Perspect. 1975 Dec;12:109-13. doi: 10.1289/ehp.7512109.

DOI:10.1289/ehp.7512109
PMID:776602
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1475024/
Abstract

Mice immunized intraperitoneally with sheep erythrocytes were treated with nickel chloride, a common particulate air pollutant. Primary antibody production in the spleen was examined using a hemolytic plaque technique. A negative linear dose-response relationship (p is less than 0.05) was observed between the logarithm of (plaques/10(6) cells) and the nickel concentration administered. Mice injected with 3.09 mug Ni2+/g body weight displayed lymphocyte function similar to that of control mice. However, injection of 9.26-12.34 mug Ni2+/g caused significant immunosupression (p is less than 0.05).

摘要

用绵羊红细胞腹腔内免疫的小鼠，用常见的颗粒状空气污染物氯化镍进行处理。使用溶血空斑技术检测脾脏中的初次抗体产生情况。在（空斑数/10⁶个细胞）的对数与所给予的镍浓度之间观察到负线性剂量反应关系（p小于0.05）。注射3.09微克Ni²⁺/克体重的小鼠表现出与对照小鼠相似的淋巴细胞功能。然而，注射9.26 - 12.34微克Ni²⁺/克体重会导致显著的免疫抑制（p小于0.05）。

相似文献

1
Effect of nickel chloride on primary antibody production in the spleen.氯化镍对脾脏中初次抗体产生的影响。
Environ Health Perspect. 1975 Dec;12:109-13. doi: 10.1289/ehp.7512109.
2
Studies on the effect of cortisol on the primary immune response to sheep erythrocytes in vivo by mouse spleen cells.关于皮质醇对小鼠脾细胞在体内对绵羊红细胞的初次免疫反应影响的研究。
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引用本文的文献

1
Toxicological effects of nickel chloride on IgA+ B Cells and sIgA, IgA, IgG, IgM in the intestinal mucosal immunity in broilers.氯化镍对肉鸡肠道黏膜免疫中IgA+ B细胞及sIgA、IgA、IgG、IgM的毒理学效应
Int J Environ Res Public Health. 2014 Aug 11;11(8):8175-92. doi: 10.3390/ijerph110808175.
2
A survey of the effect of metals on the immune response.金属对免疫反应影响的调查。
Biol Trace Elem Res. 1979 Jun;1(2):141-8. doi: 10.1007/BF02821709.
3
Antibody suppression by zinc and nickel.锌和镍对抗体的抑制作用。
Biol Trace Elem Res. 1981 Mar;3(1):7-11. doi: 10.1007/BF02789120.

本文引用的文献

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Determination of cell viability.细胞活力的测定。
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Cell to cell interaction in the immune response. II. The source of hemolysin-forming cells in irradiated mice given bone marrow and thymus or thoracic duct lymphocytes.免疫反应中的细胞间相互作用。II. 给受照射小鼠输注骨髓、胸腺或胸导管淋巴细胞后溶血素形成细胞的来源。
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Alterations in antibody response induced by chronic inhalation of SO 2 and carbon.长期吸入二氧化硫和碳导致的抗体反应变化。
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Metal toxicity for rabbit alveolar macrophages in vitro.金属对兔肺泡巨噬细胞的体外毒性作用。
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Effect of trace metals on phagocytosis by alveolar macrophages.痕量金属对肺泡巨噬细胞吞噬作用的影响。
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