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氯化镍对脾脏中初次抗体产生的影响。

Effect of nickel chloride on primary antibody production in the spleen.

作者信息

Graham J A, Gardner D E, Miller F J, Daniels M J, Coffin D L

出版信息

Environ Health Perspect. 1975 Dec;12:109-13. doi: 10.1289/ehp.7512109.

DOI:10.1289/ehp.7512109
PMID:776602
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1475024/
Abstract

Mice immunized intraperitoneally with sheep erythrocytes were treated with nickel chloride, a common particulate air pollutant. Primary antibody production in the spleen was examined using a hemolytic plaque technique. A negative linear dose-response relationship (p is less than 0.05) was observed between the logarithm of (plaques/10(6) cells) and the nickel concentration administered. Mice injected with 3.09 mug Ni2+/g body weight displayed lymphocyte function similar to that of control mice. However, injection of 9.26-12.34 mug Ni2+/g caused significant immunosupression (p is less than 0.05).

摘要

用绵羊红细胞腹腔内免疫的小鼠，用常见的颗粒状空气污染物氯化镍进行处理。使用溶血空斑技术检测脾脏中的初次抗体产生情况。在（空斑数/10⁶个细胞）的对数与所给予的镍浓度之间观察到负线性剂量反应关系（p小于0.05）。注射3.09微克Ni²⁺/克体重的小鼠表现出与对照小鼠相似的淋巴细胞功能。然而，注射9.26 - 12.34微克Ni²⁺/克体重会导致显著的免疫抑制（p小于0.05）。

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A survey of the effect of metals on the immune response.金属对免疫反应影响的调查。
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3
Antibody suppression by zinc and nickel.锌和镍对抗体的抑制作用。
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本文引用的文献

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