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Transglycosylic reactions of nucleotides of deoxy sugars. Biosynthesis of deoxy analogues of alpha,alpha'-trehalose.

作者信息

Zemek J, Strmen J, Kucar S, Bauer S

出版信息

Eur J Biochem. 1976 Apr 15;64(1):283-6. doi: 10.1111/j.1432-1033.1976.tb10298.x.

DOI:10.1111/j.1432-1033.1976.tb10298.x
PMID:776613
Abstract

The biosynthesis of alpha,alpha'-trehalose was investigated in a reaction catalyzed with yeast UDP-Glc :glucose-6-phosphate 1-glucosyl transferase. It was revealed that the hydroxyls at positions C-2, C-3, C-4 and C-6 are not essential for preserving its substrate properties in this reaction. The affinity of the enzyme and the rate of hexose incorporation into trehalose decreases in following sequence: UDP-glucose, UDP-2-deoxy-D-glucose, UDP-6-deoxy-d-glucose, UDP-4-deoxy-D-glucose and UDP-3-deoxy-D-glucose.

摘要

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