Lavrovsky V A, Razvorotnev V A
Folia Biol (Praha). 1976;22(2):108-15.
Cells from various spontaneous mammary tumours of C3H/He mice differ in their sensitivity to immune allogeneic lymphocytes in vitro. Two cell lines, differing in their sensitivity to allogeneic immune lymphocytes in vitro, were obtained from spontaneous mammary tumours which developed in C3H/He mice. Of these two lines, the cell line MT3 was considerably more immunoresistant than line MT5, as demonstrated by microcytotoxic tests in vitro. Furthermore, only the immunoresistant MT3 cell line was capable of growing in syngeneic hosts. During passages in vitro, cells of the line MT5 became as immuno-resistant as cells of the line MT3; concomitantly, cells of the line MT5 started to take in syngeneic hosts. Cell immunosensitivity to immune allogeneic lymphocytes in vitro correlates with that cell property which determines the penetrance rate of intact allogeneic and syngeneic lymphocytes into these cells (emperipolesis). Non-tumourous cells from different C3H/He mouse tissues were more immunoresistant than tumour cells from the two cell lines cultured.
来自C3H/He小鼠各种自发性乳腺肿瘤的细胞在体外对同种异体免疫淋巴细胞的敏感性不同。从C3H/He小鼠发生的自发性乳腺肿瘤中获得了两种在体外对同种异体免疫淋巴细胞敏感性不同的细胞系。在这两种细胞系中，通过体外微细胞毒性试验表明，MT3细胞系比MT5细胞系具有更强的免疫抗性。此外，只有免疫抗性的MT3细胞系能够在同基因宿主中生长。在体外传代过程中，MT5细胞系的细胞变得与MT3细胞系的细胞一样具有免疫抗性；与此同时，MT5细胞系的细胞开始在同基因宿主中生长。细胞在体外对同种异体免疫淋巴细胞的免疫敏感性与决定完整的同种异体和同基因淋巴细胞进入这些细胞的渗透率（细胞吞噬）的细胞特性相关。来自不同C3H/He小鼠组织的非肿瘤细胞比培养的两种细胞系的肿瘤细胞具有更强的免疫抗性。
