Rosen D H, Flanders W D, Friede A, Humphrey H E, Sinks T H
Centers for Disease Control and Prevention, Atlanta, GA 30341-3724, USA.
Environ Health Perspect. 1995 Mar;103(3):272-4. doi: 10.1289/ehp.95103272.
Polybrominated biphenyl (PBB), a flame-retardant material, was introduced into the food chain in Michigan in 1973 due to a manufacturing and distribution mistake. Following public concern about the long-term health effects of PBB in humans, a cohort of PBB-exposed Michigan residents was assembled in 1975. We initiated this study to determine the half-life of PBB in human sera and to understand how continued body burden relates to the possible adverse health consequences of PBB exposure. To determine the half-life, eligible persons were selected from the cohort if they had at least two PBB measurements 1 year apart and had an initial level > or = 20 pbb. There were 163 persons who met the criteria with a median PBB level of 45.5 ppb. The estimated half-life is 10.8 years (95% CI, 9.2-14.7 years). The body burden of PBB in exposed persons will decrease only gradually over time. For persons with an initial level of 45.5 ppb of PBB, it will take more than 60 years for their PBB levels to fall below the current level of detection of 1 ppb.
多溴联苯（PBB）是一种阻燃材料，1973年因生产和分销失误而进入密歇根州的食物链。在公众对PBB对人类健康的长期影响表示关注后，1975年召集了一组接触PBB的密歇根州居民。我们开展这项研究以确定PBB在人血清中的半衰期，并了解持续的体内负荷与PBB暴露可能产生的不良健康后果之间的关系。为了确定半衰期，如果符合条件的人在队列中有至少两次间隔1年的PBB测量值且初始水平≥20 ppb，则从队列中选择他们。有163人符合标准，PBB水平中位数为45.5 ppb。估计半衰期为10.8年（95%置信区间，9.2 - 14.7年）。随着时间的推移，接触者体内PBB的负荷只会逐渐降低。对于初始PBB水平为45.5 ppb的人来说，其PBB水平降至目前1 ppb的检测水平以下需要60多年时间。
