Hashimoto T, Tayama M, Miyazaki M, Fujii E, Harada M, Miyoshi H, Tanouchi M, Kuroda Y
Department of Paediatrics, Tokushima University School of Medical Sciences.
Dev Med Child Neurol. 1995 May;37(5):398-405. doi: 10.1111/j.1469-8749.1995.tb12023.x.
Volume-selective proton magnetic resonance spectroscopy (1H-MRS) of the brain was performed with a 1.5 Tesla magnet in 47 healthy children and in six healthy adults. Peaks of N-acetylaspartate (NAA), choline (Cho) and creatine (Cr) were observed in all cases, but a lactate peak was not observed. In the right parietal region. 1H-MRS revealed increases in the rations of NAAJCho and NAA/Cr and a decrease in Cho/Cr with advancing age. The most rapid changes were noted between one and three years of age. 1H-MRS of the right frontal region also was performed in 21 cases (20 children and one adult). In the right frontal region, there was an increase in the ratio of NAA/Cho and a decrease in Cho/Cr with advancing age, while a developmental change was not observed in the ratio of NAA/Cr. The ratios of both NAA/Cho and NAA/Cr were lower in the right frontal region than in the right parietal region. These results show that developmental changes and regional variation of metabolites are observed in 1H-MRS of the brain, and need to be considered in its application.
采用1.5特斯拉的磁体对47名健康儿童和6名健康成人进行了脑部容积选择性质子磁共振波谱（1H-MRS）检查。所有病例均观察到N-乙酰天门冬氨酸（NAA）、胆碱（Cho）和肌酸（Cr）的波峰，但未观察到乳酸峰。在右侧顶叶区域，1H-MRS显示随着年龄增长，NAA/Cho和NAA/Cr的比值增加，Cho/Cr的比值降低。一岁至三岁之间变化最为迅速。还对21例（20名儿童和1名成人）进行了右侧额叶区域的1H-MRS检查。在右侧额叶区域，随着年龄增长，NAA/Cho的比值增加，Cho/Cr的比值降低，而NAA/Cr的比值未观察到发育变化。右侧额叶区域的NAA/Cho和NAA/Cr比值均低于右侧顶叶区域。这些结果表明，在脑部1H-MRS中观察到了代谢物的发育变化和区域差异，在其应用中需要加以考虑。
