在智力迟钝患者体内质子磁共振波谱检查中观察到大脑中N-乙酰天门冬氨酸减少。

Reduced N-acetylaspartate in the brain observed on in vivo proton magnetic resonance spectroscopy in patients with mental retardation.

作者信息

Hashimoto T, Tayama M, Miyazaki M, Yoneda Y, Yoshimoto T, Harada M, Miyoshi H, Tanouchi M, Kuroda Y

机构信息

Department of Pediatrics, University of Tokushima School of Medicine, Japan.

出版信息

Pediatr Neurol. 1995 Oct;13(3):205-8. doi: 10.1016/0887-8994(95)00159-d.

DOI:10.1016/0887-8994(95)00159-d

PMID:8554657

Abstract

Volume-selective proton magnetic resonance spectroscopy (1H-MRS) of the brain was performed with a 1.5T magnet in 28 patients with unclassified mental retardation (MR) and in 25 age-matched healthy children. Peaks of N-acetylaspartate (NAA), choline (Cho), and creatine (Cr), but not of lactate, were observed in both groups on 1H-MRS. In all our subjects of this age range, 1H-MRS revealed an increase with advancing age in the ratio of NAA/Cho (P = .0031), but no developmental change in the NAA/Cr and Cho/Cr ratios. The NAA/Cho ratio was lower in patients with MR than in controls (P = .0016). The NAA/Cr ratio tended to be lower in the MR group, and the Cho/Cr ratio did not differ between patients with MR and controls. These results suggest that in patients with MR, NAA decreases and a disorder and/or dysfunction of neurons in the brain exists.

摘要

对28例未分类智力发育迟缓（MR）患者和25例年龄匹配的健康儿童，使用1.5T磁体进行了脑部体积选择性质子磁共振波谱（1H-MRS）检查。在两组的1H-MRS上均观察到了N-乙酰天门冬氨酸（NAA）、胆碱（Cho）和肌酸（Cr）的峰，但未观察到乳酸峰。在我们这个年龄范围的所有受试者中，1H-MRS显示NAA/Cho比值随年龄增长而增加（P = 0.0031），但NAA/Cr和Cho/Cr比值无发育性变化。MR患者的NAA/Cho比值低于对照组（P = 0.0016）。MR组的NAA/Cr比值倾向于较低，MR患者与对照组之间的Cho/Cr比值无差异。这些结果表明，在MR患者中，NAA减少，且存在大脑神经元的紊乱和/或功能障碍。