Hashimoto T, Tayama M, Miyazaki M, Yoneda Y, Yoshimoto T, Harada M, Miyoshi H, Tanouchi M, Kuroda Y
Department of Pediatrics, University of Tokushima School of Medicine, Japan.
Pediatr Neurol. 1995 Oct;13(3):205-8. doi: 10.1016/0887-8994(95)00159-d.
Volume-selective proton magnetic resonance spectroscopy (1H-MRS) of the brain was performed with a 1.5T magnet in 28 patients with unclassified mental retardation (MR) and in 25 age-matched healthy children. Peaks of N-acetylaspartate (NAA), choline (Cho), and creatine (Cr), but not of lactate, were observed in both groups on 1H-MRS. In all our subjects of this age range, 1H-MRS revealed an increase with advancing age in the ratio of NAA/Cho (P = .0031), but no developmental change in the NAA/Cr and Cho/Cr ratios. The NAA/Cho ratio was lower in patients with MR than in controls (P = .0016). The NAA/Cr ratio tended to be lower in the MR group, and the Cho/Cr ratio did not differ between patients with MR and controls. These results suggest that in patients with MR, NAA decreases and a disorder and/or dysfunction of neurons in the brain exists.
对28例未分类智力发育迟缓（MR）患者和25例年龄匹配的健康儿童，使用1.5T磁体进行了脑部体积选择性质子磁共振波谱（1H-MRS）检查。在两组的1H-MRS上均观察到了N-乙酰天门冬氨酸（NAA）、胆碱（Cho）和肌酸（Cr）的峰，但未观察到乳酸峰。在我们这个年龄范围的所有受试者中，1H-MRS显示NAA/Cho比值随年龄增长而增加（P = 0.0031），但NAA/Cr和Cho/Cr比值无发育性变化。MR患者的NAA/Cho比值低于对照组（P = 0.0016）。MR组的NAA/Cr比值倾向于较低，MR患者与对照组之间的Cho/Cr比值无差异。这些结果表明，在MR患者中，NAA减少，且存在大脑神经元的紊乱和/或功能障碍。
