Reif S, Klein I, Arber N, Gilat T
Department of Gastroenterology, Tel Aviv Sourasky Medical Center, Israel.
Gastroenterology. 1995 Jun;108(6):1683-7. doi: 10.1016/0016-5085(95)90129-9.
BACKGROUND/AIMS: An excess of smokers in patients with Crohn's disease (CD) and a paucity of smokers in patients with ulcerative colitis (UC) were reported in many studies. The aim of this study was to examine the association between smoking and inflammatory bowel disease (IBD) in Israel.
Two independent studies were performed. Patients with recent IBD in comparison with matched population and outpatient controls and patients with chronic UC and CD were studied. Altogether, 475 subjects were investigated.
In both studies, the presence of current smokers was lower in CD (9% and 18%) than in UC (24% and 26%). The proportions of nonsmokers in both studies were similar (UC, 61% and 65%; CD, 67% and 70%) and comparable to those found in their two control groups (57% and 61%; 63% and 68%, respectively) and to the general population of Israel. All differences in smoking habits between patient groups and their controls were not statistically significant, except for the paucity of current smokers in the small group of patients with newly diagnosed CD (P < 0.05). A matched analysis produced similar results.
The expected associations between smoking and IBD could not be confirmed. Two hypotheses are considered: (1) the association between smoking and IBD may not be universal, and (2) our findings may be related to the higher genetic predisposition to IBD in Jewish people.
背景/目的：许多研究报告称，克罗恩病（CD）患者中吸烟者过多，而溃疡性结肠炎（UC）患者中吸烟者较少。本研究旨在探讨以色列吸烟与炎症性肠病（IBD）之间的关联。
进行了两项独立研究。对近期患IBD的患者与匹配的人群及门诊对照进行比较，并对慢性UC和CD患者进行研究。总共调查了475名受试者。
在两项研究中，CD患者中当前吸烟者的比例（分别为9%和18%）低于UC患者（分别为24%和26%）。两项研究中不吸烟者的比例相似（UC分别为61%和65%；CD分别为67%和70%），与两个对照组中的比例（分别为57%和61%；63%和68%）以及以色列普通人群相当。患者组与其对照组之间吸烟习惯的所有差异均无统计学意义，但新诊断的CD患者小群体中当前吸烟者较少除外（P < 0.05）。匹配分析得出了相似的结果。
吸烟与IBD之间预期的关联未能得到证实。考虑了两种假设：（1）吸烟与IBD之间的关联可能并非普遍存在；（2）我们的发现可能与犹太人中IBD的遗传易感性较高有关。
