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[早期胃癌:胃癌大规模筛查项目的主要目标]

[Early gastric cancer: main objective in a mass screening program for gastric cancer].

作者信息

Oliver W

机构信息

Centro de Control de Cáncer Gastrointestinal San Cristobal-Edo, Táchira.

出版信息

G E N. 1994 Jul-Sep;48(3):144-56.

PMID:7768419
Abstract

In Táchira's State, Venezuela, there is a high incidence of Gastric Cancer. Screening for early gastric cancer (EGC) detection began in 1981. It observes the Japanese model, with Indirect Radiological (IR) as the move to the various Municipalities, offering the screening test. Subjects with IR abnormalities receive an invitation for an endoscopic examination. If lesions at endoscopy, biopsies were taken. Treatable patients went to surgery; the diagnosis on the surgical specimen was fulfilled by trained Pathologists. CGs cases are actively followed up. From 1981 to 1992 we did 150.023 radiological studies 52.562 gastric endoscopies and 18,480 endoscopic biopsies. We diagnosed 612 CGs:450 were advanced: 102 patients with 113 EGCs with confirmation after surgery; 60 cases were suspected by radiology and endoscopy as EGCs but were nor confirmed because the patients were not operated. 89 patients underwent gastroectomies, and 13 endoscopy resections. The EGCs were depressed (Types IIc, III) in 49% elevated (Types I, IIa) 26%, flat (Type IIb) 6% and intermediate (Types IIa + IIc) 19%. The invasion was confined to the mucosa in 60% and to the submucosa in 40%. By histopathology 60% were differentiated and 40% undifferentiated. In 9% we found metastasis in lymph nodes, only in 2% of the mucosal ones. Survival of patients with EGC after 5 year was 93%. We think a secondary prevention can be done in high risk regions through an appropriate screening for EGC.

摘要

在委内瑞拉的塔奇拉州,胃癌发病率很高。早期胃癌(EGC)筛查于1981年开始。它采用日本模式,通过间接放射学检查(IR)在各个城市进行筛查测试。IR检查结果异常的受试者会收到内镜检查的邀请。如果在内镜检查中发现病变,则进行活检。可治疗的患者接受手术;手术标本的诊断由训练有素的病理学家完成。对胃癌病例进行积极随访。1981年至1992年期间,我们进行了150023次放射学检查、52562次胃镜检查和18480次内镜活检。我们诊断出612例胃癌:450例为进展期;102例患者有113例早期胃癌,术后得到确诊;60例经放射学和内镜检查怀疑为早期胃癌,但因患者未接受手术而未得到确诊。89例患者接受了胃切除术,13例接受了内镜切除术。早期胃癌中凹陷型(IIc型、III型)占49%,隆起型(I型、IIa型)占26%,平坦型(IIb型)占6%,混合型(IIa + IIc型)占19%。60%的肿瘤侵犯局限于黏膜层,40%侵犯至黏膜下层。组织病理学检查显示,60%为分化型,40%为未分化型。9%的患者发现有淋巴结转移,仅2%的黏膜层肿瘤出现淋巴结转移。早期胃癌患者5年后的生存率为93%。我们认为,通过对早期胃癌进行适当筛查,可在高危地区开展二级预防。

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