Job C K, Chacko C J, Taylor P M, Daniel M, Jesudian G
Int J Lepr Other Mycobact Dis. 1976 Jan-Jun;44(1-2):256-66.
Lymphocyte transformation in response to PHA, M. leprae and BCG with the use of measurements of 3H-thymidine uptake, was studied in 10 normal controls, and 71 leprosy patients of different types histologically classified according to the Ridley-Jopling scale. Lepromin and PPD tests were done in each one of them. It was found that there was a generalized depression of immune responsiveness to PHA in all forms of leprosy. The immune responsiveness of lymphocytes to M. leprae continuously and gradually increases from the lepromatous (LL) towards the tuberculoid (TT) end of the spectrum. The loss of immune response of lymphocytes from lepromatous patients to M. leprae is specific as evidenced by their capacity to respond selectively to BCG when PPD-positive, irrespective of their place in the leprosy spectrum.
利用³H-胸腺嘧啶核苷摄取量测量法，对10名正常对照者以及71名根据里德利-乔普林量表进行组织学分类的不同类型麻风患者，研究了其对PHA、麻风杆菌和卡介苗的淋巴细胞转化情况。对他们每个人都进行了麻风菌素和PPD试验。结果发现，在所有形式的麻风病中，对PHA的免疫反应普遍受到抑制。淋巴细胞对麻风杆菌的免疫反应从瘤型（LL）到结核样型（TT）端呈连续且逐渐增强的趋势。瘤型患者淋巴细胞对麻风杆菌的免疫反应丧失具有特异性，这一点可通过PPD呈阳性时他们对卡介苗有选择性反应的能力得到证明，而不论其在麻风病谱中的位置如何。
