突变丝状噬菌体单链DNA诱导大肠杆菌中的SOS反应：通过LexA阻遏物的切割进行监测
SOS induction in Escherichia coli by single-stranded DNA of mutant filamentous phage: monitoring by cleavage of LexA repressor.
作者信息
Higashitani N, Higashitani A, Horiuchi K
机构信息
Division of Microbial Genetics, National Institute of Genetics, Mishima, Japan.
出版信息
J Bacteriol. 1995 Jun;177(12):3610-2. doi: 10.1128/jb.177.12.3610-3612.1995.
Abstract
Infection of Escherichia coli in the presence of chloramphenicol with mutant filamentous phage that are defective in the initiation of minus-strand DNA synthesis induces the SOS response as monitored by cellular LexA levels. This observation demonstrates that single-stranded DNA serves as a primary signal for SOS induction in vivo.
摘要
在氯霉素存在的情况下，用负链DNA合成起始有缺陷的突变丝状噬菌体感染大肠杆菌，会诱导SOS反应，这可通过细胞LexA水平来监测。这一观察结果表明，单链DNA在体内是SOS诱导的主要信号。
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