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Topoisomerase activity during the heat shock response in Escherichia coli K-12.大肠杆菌K-12热休克反应期间的拓扑异构酶活性
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2
Roles of topoisomerases in maintaining steady-state DNA supercoiling in Escherichia coli.拓扑异构酶在维持大肠杆菌稳态DNA超螺旋中的作用。
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4
Altered topoisomerase activities may be involved in the regulation of DNA supercoiling in aerobic-anaerobic transitions in Escherichia coli.拓扑异构酶活性的改变可能参与了大肠杆菌有氧-厌氧转变过程中DNA超螺旋的调控。
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Characterization of twenty-six new heat shock genes of Escherichia coli.大肠杆菌26个新热休克基因的特性分析
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Topoisomerase mutations affect the relative abundance of many Escherichia coli proteins.拓扑异构酶突变会影响许多大肠杆菌蛋白质的相对丰度。
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Effect of nalidixic acid and novobiocin on pBR322 genetic expression in Escherichia coli minicells.萘啶酸和新生霉素对大肠杆菌微小细胞中pBR322基因表达的影响。
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Regulation of bacterial DNA supercoiling: plasmid linking numbers vary with growth temperature.细菌DNA超螺旋的调控：质粒连环数随生长温度而变化。
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Regulation of the genes for E. coli DNA gyrase: homeostatic control of DNA supercoiling.大肠杆菌DNA促旋酶基因的调控：DNA超螺旋的稳态控制
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Escherichia coli DNA topoisomerase I mutants: increased supercoiling is corrected by mutations near gyrase genes.大肠杆菌DNA拓扑异构酶I突变体：超螺旋增加可通过gyrase基因附近的突变得到纠正。
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Chromosomes in living Escherichia coli cells are segregated into domains of supercoiling.活的大肠杆菌细胞中的染色体被分隔成超螺旋结构域。
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Biology of bacterial deoxyribonucleic acid topoisomerases.细菌脱氧核糖核酸拓扑异构酶的生物学
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Changes in the linking number of supercoiled DNA accompany growth transitions in Escherichia coli.超螺旋DNA连接数的变化伴随着大肠杆菌的生长转变。
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大肠杆菌K-12热休克反应期间的拓扑异构酶活性

Topoisomerase activity during the heat shock response in Escherichia coli K-12.

作者信息

Camacho-Carranza R, Membrillo-Hernández J, Ramírez-Santos J, Castro-Dorantes J, Chagoya de Sánchez V, Gómez-Eichelmann M C

机构信息

Departamento de Biología Molecular, Universidad Nacional Autónoma de México, México, D.F.

出版信息

J Bacteriol. 1995 Jun;177(12):3619-22. doi: 10.1128/jb.177.12.3619-3622.1995.

DOI:10.1128/jb.177.12.3619-3622.1995
PMID:7768879
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC177075/
Abstract

During the upshift of temperature from 30 to 42, 45, 47, or 50 degrees C, an increase in the level of supercoiling of a reporter plasmid was observed. This increase was present in groE and dnaK mutants but was inhibited in cells treated with chloramphenicol and novobiocin. The intracellular [ATP]/[ADP] ratio increased rapidly after an upshift in temperature from 30 to 47 degrees C and then decreased to reach a level above that observed at 30 degrees C. These results suggest that gyrase and proteins synthesized during heat shock are responsible for the changes seen in plasmid supercoiling. Proteins GroE and DnaK are probably not involved in this phenomenon.

摘要

在温度从30℃上升至42℃、45℃、47℃或50℃的过程中，观察到报告质粒的超螺旋水平增加。这种增加在groE和dnaK突变体中存在，但在用氯霉素和新生霉素处理的细胞中受到抑制。当温度从30℃上升至47℃后，细胞内[ATP]/[ADP]比值迅速增加，然后下降至高于30℃时观察到的水平。这些结果表明，热休克期间合成的gyrase和蛋白质是质粒超螺旋变化的原因。蛋白质GroE和DnaK可能不参与这一现象。