Bustillo M, Krysa L W, Coulam C B
Genetics & IVF Institute, Fairfax, VA, USA.
Hum Reprod. 1995 Feb;10(2):442-5. doi: 10.1093/oxfordjournals.humrep.a135959.
Oocyte donation is a useful model for the assessment of potential factors affecting implantation since embryos generated are from younger oocytes than in in-vitro fertilization programmes and are therefore expected to have higher and more consistent implantation rates. Transvaginal sonographic measurement of endometrial thickness, echogenic pattern and uterine artery impedance, measured as pulsatility index (PI) and resistance index (RI), were retrospectively compared in 99 recipient women following 117 fresh embryo transfers that resulted in 51 conception cycles and 66 non-conception cycles. The prevalence of a multilayered echogenic pattern was significantly greater (91.2%) in conception than in non-conception (44.4%) cycles. No differences in endometrial thickness, PI or RI were observed between conception and non-conception cycles. However, no pregnancy occurred when the PI was > or = 3.4 (sensitivity 100%). The number of days or cumulative dose of oestrogen intake and the serum oestradiol concentration prior to progesterone administration were not different in the multilayered pattern versus other echogenic pattern groups. The data show that it may be beneficial to await achievement of a PI < 3.4 and a multilayered pattern endometrium prior to embryo transfer in an oocyte donation programme.
卵母细胞捐赠是评估影响着床潜在因素的一个有用模型，因为所产生的胚胎来自比体外受精方案中更年轻的卵母细胞，因此预计具有更高且更一致的着床率。对99名接受者在117次新鲜胚胎移植后的情况进行了回顾性比较，这些移植导致了51个受孕周期和66个未受孕周期，测量了子宫内膜厚度、回声模式以及子宫动脉阻抗（以搏动指数（PI）和阻力指数（RI）衡量）。多层回声模式在受孕周期中的发生率（91.2%）显著高于未受孕周期（44.4%）。在受孕周期和未受孕周期之间，未观察到子宫内膜厚度、PI或RI存在差异。然而，当PI≥3.4时未发生妊娠（敏感性100%）。多层模式组与其他回声模式组在服用雌激素的天数或累积剂量以及给予孕激素前的血清雌二醇浓度方面并无差异。数据表明，在卵母细胞捐赠方案中，胚胎移植前等待PI<3.4且子宫内膜呈多层模式可能是有益的。
