C-2801X，一种新型头孢霉素类抗生素II。分离与特性鉴定。

C-2801X, a new cephamycin-type antibiotic II. Isolation and characterization.

作者信息

Fukase H, Hasegawa T, Hatano K, Iwasaki H, Yoneda M

出版信息

J Antibiot (Tokyo). 1976 Feb;29(2):113-20. doi: 10.7164/antibiotics.29.113.

DOI:10.7164/antibiotics.29.113

Abstract

Two new species of Streptomyces, S. heteromorphus and heteromorphus and S. panayensis, were found to produce a new atibiotic named C-2801X together with cephamycins A and B. The antibiotics were separated from each other by column chromatography on Amberlite XAD-2 and isolated in pure form as mono-sodium salts. C-2801X mono-sodium salt has a molecular formula C25H28N3O12SNa, and exhibits antibacterial activity against Gram-positive and Gram-negative bacteria including those insensitive to cephamycins A and B. From its physicochemical and biological properties, C2801X was considered to be a new cephamycin-type antibiotic.

摘要

发现两种新的链霉菌，异形链霉菌（Streptomyces heteromorphus）和班乃岛链霉菌（Streptomyces panayensis），可产生一种名为C-2801X的新抗生素以及头孢霉素A和B。通过在Amberlite XAD-2上进行柱色谱法将这些抗生素彼此分离，并以单钠盐的形式分离得到纯品。C-2801X单钠盐的分子式为C25H28N3O12SNa，对革兰氏阳性菌和革兰氏阴性菌均具有抗菌活性，包括那些对头孢霉素A和B不敏感的细菌。从其理化性质和生物学特性来看，C2801X被认为是一种新型的头孢霉素类抗生素。