绿灰链霉菌新型头孢霉素的发现、分离与结构研究

Discovery, isolation and structure of novel cephamycins of Streptomyces chartreusis.

作者信息

Inouye S, Kojima M, Shomura T, Iwamatsu K, Niwa T, Kondo Y, Niida T, Ogawa Y, Kusama K

出版信息

J Antibiot (Tokyo). 1983 Feb;36(2):115-24. doi: 10.7164/antibiotics.36.115.

DOI:10.7164/antibiotics.36.115

Abstract

By the use of HPLC technique after treatment with beta-lactamases, two novel cephamycins, SF-1623 and SF-1623B, were discovered and isolated from the fermentation broth of Streptomyces chartreusis SF-1623. The structures of SF-1623 and SF-1623B were determined to contain 3-sulfothiomethyl and 3-hydroxymethyl groups respectively, by chemical and enzymatic transformation reactions. Studies on the fermentation condition and process for the large scale preparation of antibiotic SF-1623 are also described.

摘要

在用β-内酰胺酶处理后，通过高效液相色谱（HPLC）技术，从浅蓝链霉菌SF-1623的发酵液中发现并分离出了两种新型头孢霉素，即SF-1623和SF-1623B。通过化学和酶促转化反应确定，SF-1623和SF-1623B的结构分别含有3-硫代甲基磺酰基和3-羟甲基。本文还描述了抗生素SF-1623大规模制备的发酵条件和工艺研究。