McKinley M, Leibowitz S, Bronzo R, Zanzi I, Weissman G, Schiffman G
Department of Medicine, North Shore University Hospital, Manhasset, NY 11030, USA.
J Clin Gastroenterol. 1995 Mar;20(2):113-6. doi: 10.1097/00004836-199503000-00008.
Hyposplenism as a complication of celiac sprue confers an increased risk of pneumococcal sepsis, but such patients do not routinely receive pneumococcal vaccine despite reports of overwhelming pneumococcal sepsis. Because antibody response in these patients has not been previously assessed, we measured pre- and postvaccination levels in 10 patients with documented sprue. All demonstrated appropriate acute antibody responses to a polyvalent pneumococcal vaccine. Vaccination of all patients with celiac sprue seems appropriate.
作为乳糜泻并发症的脾功能减退会增加肺炎球菌败血症的风险，但尽管有严重肺炎球菌败血症的报道，这类患者通常并不常规接种肺炎球菌疫苗。由于此前未评估过这些患者的抗体反应，我们测量了10例确诊乳糜泻患者接种疫苗前后的抗体水平。所有患者对多价肺炎球菌疫苗均表现出适当的急性抗体反应。对所有乳糜泻患者进行疫苗接种似乎是合适的。
