Pawlotsky J M, Tsakiris L, Roudot-Thoraval F, Pellet C, Stuyver L, Duval J, Dhumeaux D
Department of Bacteriology and Virology, Hôpital Henri Mondor, Université Paris XII, Créteil, France.
J Infect Dis. 1995 Jun;171(6):1607-10. doi: 10.1093/infdis/171.6.1607.
This study examined the relationships between hepatitis C virus (HCV) genotypes and the routes of HCV transmission in 101 patients with chronic hepatitis C. Patients who received blood transfusions (43%) and those with chronic hepatitis C of unknown cause (37%) had similar mean ages, age distribution, and HCV genotype distribution (1a, 19% vs. 14%; 1b, 52% vs. 54%; 3a, 10% vs. 9%; other, 19% vs. 23%). Intravenous drug users (IVDUs) were significantly younger and had a different genotype distribution (1a, 33%; 1b, 0; 3a, 63%; other, 5%; P < .001). Transmission of HCV 3a has been observed only over the past 20 years; other genotypes were transmitted up to 40 years ago. These results suggest that for 20 years there have been two independent ongoing hepatitis C epidemics. One affects persons who received blood transfusions or whose source of infection is unknown. These persons are older and are mainly infected by HCV 1b. The second type of infection occurs in IVDUs and infects younger persons, mainly with HCV 3a.
本研究调查了101例慢性丙型肝炎患者丙型肝炎病毒（HCV）基因型与HCV传播途径之间的关系。接受输血的患者（43%）和病因不明的慢性丙型肝炎患者（37%）的平均年龄、年龄分布及HCV基因型分布相似（1a型，分别为19%和14%；1b型，分别为52%和54%；3a型，分别为10%和9%；其他型，分别为19%和23%）。静脉吸毒者（IVDUs）明显更年轻，且基因型分布不同（1a型，33%；1b型，0；3a型，63%；其他型，5%；P<0.001）。HCV 3a型的传播仅在过去20年中被观察到；其他基因型的传播则可追溯到40年前。这些结果表明，在过去20年里存在两种独立且持续的丙型肝炎流行情况。一种影响接受输血者或感染源不明者。这些人年龄较大，主要感染HCV 1b型。第二种感染类型发生在静脉吸毒者中，感染较年轻的人，主要是HCV 3a型。
