Kawada E, Shinonome S, Tamura J, Murakami H
Department of Internal Medicine, Tano General Hospital, Gunma, Japan.
J Med. 1994;25(6):388-92.
We describe here a patient with chronic hepatitis C and liver hemosiderosis whose serum ferritin level was notably reduced by long-term interferon-alpha (IFN alpha) therapy. The decrease of the elevated serum ferritin level was considered to have been mostly obtained by the improvement of liver dysfunction. However, at the beginning of the therapy, in spite of alanine aminotransferase (ALT) improvement, his serum ferritin level increased transiently, and after cessation of IFN alpha therapy, the serum ALT increased again, but the serum ferritin had not increased. This indicates that IFN alpha has an effect on the iron-related measurement, partly due to improvement of hepatic status.
我们在此描述一名患有慢性丙型肝炎和肝铁沉着症的患者，其血清铁蛋白水平通过长期α干扰素（IFNα）治疗显著降低。血清铁蛋白水平升高的降低被认为主要是由于肝功能障碍的改善。然而，在治疗开始时，尽管丙氨酸氨基转移酶（ALT）有所改善，但其血清铁蛋白水平短暂升高，并且在IFNα治疗停止后，血清ALT再次升高，但血清铁蛋白并未升高。这表明IFNα对铁相关指标有影响，部分原因是肝脏状况的改善。
