Barasch E, Benderly M, Graff E, Behar S, Reicher-Reiss H, Caspi A, Pelled B, Reisin L, Roguin N, Goldbourt U
BIP Coordinating Center, Neufeld Cardiac Research Institute, Sheba Medical Center, Tel-Hashomer, Israel.
J Clin Epidemiol. 1995 Jun;48(6):757-65. doi: 10.1016/0895-4356(94)00191-r.
The association between fibrinogen measured in healthy individuals and subsequent development of ischemic heart disease is well established, but studies reporting fibrinogen levels in coronary heart disease patients are scarce. Plasma fibrinogen was determined for 5729 men and 728 women (aged 45 to 74) with established coronary heart disease, screened for participation in the Bezafibrate Infarction Prevention study, with the following lipid profile at the time of the first screening visit: total serum cholesterol < or = 270 mg/dl, high density lipoprotein cholesterol < or = 45 mg/dl and triglyceride < or = 300 mg/dl. Increased age was associated with augmented plasma fibrinogen values. Age-adjusted fibrinogen levels were higher in women than in men. A direct association was found between mean fibrinogen levels and low density lipoprotein cholesterol. On the other hand, the correlation with high density lipoprotein cholesterol was inverse. Fibrinogen was also associated with body mass index, behavioral variables and severity of coronary heart disease. In a multivariable linear regression analysis performed, risk factors considered explained merely 6 and 4% of fibrinogen variation for men and women, respectively. Therefore, most of the fibrinogen level variability in coronary heart disease patients is accounted for by factors that remain to be established by further research.
健康个体中测得的纤维蛋白原与随后发生缺血性心脏病之间的关联已得到充分证实，但报告冠心病患者纤维蛋白原水平的研究却很少。对5729名男性和728名女性（年龄在45至74岁之间）已确诊的冠心病患者进行了血浆纤维蛋白原测定，这些患者被筛选参加苯扎贝特预防心肌梗死研究，在首次筛查就诊时具有以下血脂谱：总血清胆固醇≤270mg/dl，高密度脂蛋白胆固醇≤45mg/dl，甘油三酯≤300mg/dl。年龄增加与血浆纤维蛋白原值升高相关。年龄调整后的纤维蛋白原水平女性高于男性。发现平均纤维蛋白原水平与低密度脂蛋白胆固醇之间存在直接关联。另一方面，与高密度脂蛋白胆固醇的相关性呈负相关。纤维蛋白原还与体重指数、行为变量和冠心病严重程度相关。在进行的多变量线性回归分析中，所考虑的危险因素分别仅解释了男性和女性纤维蛋白原变异的6%和4%。因此，冠心病患者中纤维蛋白原水平的大部分变异性是由有待进一步研究确定的因素造成的。
