Dekker J M, Schouten E G, Kromhout D, Klootwijk P, Pool J
Department of Epidemiology and Public Health, Wageningen Agricultural University, The Netherlands.
J Clin Epidemiol. 1995 Jun;48(6):833-40. doi: 10.1016/0895-4356(94)00175-p.
The Cardiac Infarction Injury Score (CIIS), based on electrocardiographic characteristics, was developed as a measure to determine the presence of myocardial infarctions. In the present study the association of the CIIS with coronary morbidity and mortality was investigated among middle-aged and elderly men. A cohort of 877 men, born between 1900 and 1919, was followed and repeatedly examined from 1960 onwards. In 1985 the remaining cohort was extended to 836 elderly men from the same birth cohort, and followed until 1990. In both middle-aged and elderly men with high CIIS the prevalence of (silent) previous myocardial infarction and the occurrence of ST-T abnormalities were increased. Five-year relative risks of men with CIIS 20 or more relative to men with CIIS < 5 were 2.2 (95% confidence interval: 1.2-4.1) for angina pectoris, 2.4 (1.4-4.0) for myocardial infarction and 5.8 (3.4-9.9) for coronary heart disease death. Thus, the CIIS is associated with risk of coronary heart disease in apparently healthy middle-aged as well as elderly men.
基于心电图特征的心肌梗死损伤评分（CIIS）被开发出来作为一种确定心肌梗死存在的测量方法。在本研究中，对中年和老年男性中CIIS与冠心病发病率和死亡率之间的关联进行了调查。对一组877名出生于1900年至1919年之间的男性进行随访，并从1960年起反复进行检查。1985年，剩余队列扩展至来自同一年龄队列的836名老年男性，并随访至1990年。在CIIS高的中年和老年男性中，既往（无症状）心肌梗死的患病率和ST-T异常的发生率均有所增加。CIIS为20或更高的男性相对于CIIS<5的男性，心绞痛的5年相对风险为2.2（95%置信区间：1.2 - 4.1），心肌梗死为2.4（1.4 - 4.0），冠心病死亡为5.8（3.4 - 9.9）。因此，CIIS与明显健康的中年和老年男性患冠心病的风险相关。
