Verweij A M, Hordijk M L, Lipman P J
Department of General Chemistry, Forensic Science Laboratory of the Ministry of Justice, Rijswijk, The Netherlands.
J Anal Toxicol. 1995 Mar-Apr;19(2):65-8. doi: 10.1093/jat/19.2.65.
The results of a liquid chromatographic-mass spectrometric method for the quantitative determination of some medicaments of the methadone, butyrophenone, or diphenylbutylpiperidine groups in whole blood are presented. The method includes an extraction procedure with Bond Elut columns. The liquid chromatograph is connected to a mass spectrometer by a thermospray interface, and to obtain as high a sensitivity and selectivity as possible, a selected reaction monitoring mass spectrometric technique in the daughter ion mode is applied.
介绍了一种采用液相色谱 - 质谱法对全血中某些美沙酮、丁酰苯或二苯基丁基哌啶类药物进行定量测定的方法。该方法包括使用Bond Elut柱的萃取步骤。液相色谱仪通过热喷雾接口与质谱仪相连，为了获得尽可能高的灵敏度和选择性，采用了子离子模式下的选择反应监测质谱技术。
