Keye W R, Jaffe R B
J Clin Endocrinol Metab. 1976 Jun;42(6):1133-8. doi: 10.1210/jcem-42-6-1133.
Gonadotropin responses to synthetic gonadotropin-releasing hormone (GnRH or LRF), as well as basal concentrations of gonadogropins, estradiol, and prolactin, were determined at weekly intervals during the first eight weeks post partum in seven non-nursing, non-steroid-treated women. The results were compared with those of a group of eleven women studied on the second day of the menstrual cycle. In the postpartum group, baseline concentrations of LH and FSH similar to those seen in the early follicular phase of the menstrual cycle occurred by the third week post partum. In response to an iv bolus of 100 mug GnRH, elevations of serum LH: 1) occurred as early as the second postpartum week; 2) were less than those of women during the early follicular phase until the fourth postpartum week; and 3) were exaggerated (when compared with those ob subjects in the early follicular phase) during the fifth through the eighth week post partum. Similarly, the FSH responses to GnRH in the puerperium were similar to those of the subjects during the early follicular phase by the third week post partum, and were exaggerated during the second month post partum. These studies demonstrate that human pregnancy is followed by a period of relative pituitary refractoriness followed by one of increased responsiveness to GnRH.
在产后的头八周内，对七名未哺乳、未接受类固醇治疗的女性每隔一周测定一次促性腺激素对合成促性腺激素释放激素（GnRH或LRF）的反应，以及促性腺激素、雌二醇和催乳素的基础浓度。将结果与一组在月经周期第二天进行研究的11名女性的结果进行比较。在产后组中，产后第三周时LH和FSH的基线浓度与月经周期卵泡早期所见相似。静脉注射100微克GnRH后，血清LH升高：1）最早在产后第二周出现；2）直到产后第四周，升高幅度小于卵泡早期女性；3）在产后第五周至第八周期间（与卵泡早期受试者相比）升高幅度增大。同样，产后FSH对GnRH的反应在产后第三周时与卵泡早期受试者相似，在产后第二个月时升高幅度增大。这些研究表明，人类妊娠后会有一段垂体相对不应期，随后是对GnRH反应性增加的时期。
