Dworkin S I, Gleeson S, Meloni D, Koves T R, Martin T J
Department of Physiology and Pharmacology, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, NC 27157-1083, USA.
Psychopharmacology (Berl). 1995 Feb;117(3):257-61. doi: 10.1007/BF02246099.
The effects of ibogaine (40 and 80 mg/kg, i.p.), an indole alkaloid proposed for the treatment of drug abuse, were determined in three different groups of rats responding under an FR10 schedule of food, cocaine or heroin reinforcement. Ibogaine (80 mg/kg, i.p.) given 60 min before the start of the session resulted in a 97% decrease in the number of ratios completed under the food reinforcement schedule and resulted in a decrease in responding the following day. Neither 40 mg/kg ibogaine given 60 min prior to the session nor 80 mg/kg given 24 h before the session suppressed responding maintained by cocaine infusions (0.33 mg/infusion). Pretreatment with 80 mg/kg ibogaine either 60 or 90 min prior to the session suppressed cocaine self-administration on the day it was administered and the longer pretreatment continued to suppress responding for 48 h. Responding maintained by heroin (18 micrograms/infusion) was the most sensitive to the effects of ibogaine. Both 40 and 80 mg/kg ibogaine resulted in an almost complete suppression of responding following a 60-min pretreatment period. Responding maintained by heroin returned to control levels the day following the administration of ibogaine.
伊博格碱（腹腔注射，40毫克/千克和80毫克/千克）是一种被提议用于治疗药物滥用的吲哚生物碱，我们在三组分别按照FR10程序以食物、可卡因或海洛因强化反应的大鼠中测定了其效果。在实验开始前60分钟给予伊博格碱（80毫克/千克，腹腔注射），导致在食物强化程序下完成的比率数量减少了97%，并导致次日反应减少。在实验前60分钟给予40毫克/千克伊博格碱或在实验前24小时给予80毫克/千克伊博格碱，均未抑制由可卡因输注（0.33毫克/输注）维持的反应。在实验前60分钟或90分钟用80毫克/千克伊博格碱预处理，在给药当天抑制了可卡因自我给药，且较长时间的预处理在48小时内持续抑制反应。由海洛因（18微克/输注）维持的反应对伊博格碱的作用最敏感。在60分钟预处理期后，40毫克/千克和80毫克/千克的伊博格碱均导致反应几乎完全被抑制。在给予伊博格碱后的第二天，由海洛因维持的反应恢复到对照水平。
