Brown Alan S, Schaefer Catherine A, Wyatt Richard J, Begg Melissa D, Goetz Raymond, Bresnahan Michaeline A, Harkavy-Friedman Jill, Gorman Jack M, Malaspina Dolores, Susser Ezra S
Department of Psychiatry, College of Physicians and Surgeons of Columbia University, USA.
Am J Psychiatry. 2002 Sep;159(9):1528-33. doi: 10.1176/appi.ajp.159.9.1528.
The study examined the relation between paternal age at the time of birth and risk of schizophrenia in the adult offspring.
Data from the birth cohort of the Prenatal Determinants of Schizophrenia study were used in this study. Virtually all members of this birth cohort had prospective information about paternal age at the time of the offspring's birth. Subjects with schizophrenia and other schizophrenia spectrum disorders (N=71) among members of this birth cohort were previously ascertained. In separate analyses, paternal age was modeled as a continuous variable and as a categorical variable, and its relation with the risk of adult schizophrenia and other schizophrenia spectrum disorders and with the risk of schizophrenia separately were examined.
There was a marginally significant, monotonic association between advancing paternal age and risk of adult schizophrenia and schizophrenia spectrum disorders. The association held after the analysis controlled for the effects of maternal age and other potential confounders. Similar results were observed when only subjects with schizophrenia were included in the analysis.
Advanced paternal age at the time of birth of the offspring may be a risk factor for adult schizophrenia.
本研究探讨子代出生时父亲年龄与成年子代患精神分裂症风险之间的关系。
本研究使用了精神分裂症产前决定因素研究的出生队列数据。该出生队列的几乎所有成员都有子代出生时父亲年龄的前瞻性信息。此前已确定该出生队列成员中患有精神分裂症和其他精神分裂症谱系障碍的受试者(N = 71)。在单独分析中,将父亲年龄建模为连续变量和分类变量,并分别检验其与成年精神分裂症和其他精神分裂症谱系障碍风险以及与精神分裂症风险的关系。
父亲年龄增长与成年精神分裂症和精神分裂症谱系障碍风险之间存在微弱但显著的单调关联。在分析控制了母亲年龄和其他潜在混杂因素的影响后,该关联依然存在。当分析仅纳入患有精神分裂症的受试者时,观察到了类似结果。
子代出生时父亲年龄较大可能是成年精神分裂症的一个风险因素。