Effects of pineal body and melatonin on lymphocyte proliferation and dinoprostone production in rat spleen.
作者信息
Ding C H, Wei W, Xu S Y
机构信息
Institute of Clinical Pharmacology, Anhui Medical University, Hefei, China.
出版信息
Zhongguo Yao Li Xue Bao. 1995 Jan;16(1):54-7.
AIM
To determine the effects of pineal body and melatonin (Mel) on lymphocyte proliferation and dinoprostone production in rat spleen.
METHODS
Pinealectomy (PE), lymphocyte proliferation assay and dinoprostone radioimmunoassay were used.
RESULTS
A circadian rhythm of splenic lymphocyte proliferation which peaked at 22:00 was obliterated by PE in rats. PE led to an impairment of lymphocyte proliferation and an increase of dinoprostone production, which were restored by ip Mel 10 micrograms.kg-1.d-1 at 16:00 for 7 d. Mel promoted lymphocyte proliferation and inhibited dinoprostone production in intact rats. A negative correlation between the change in lymphocyte proliferation and dinoprostone production was seen.
CONCLUSION
The pineal body and its main hormone Mel play a regulatory role in circadian lymphocyte proliferation which is related to dinoprostone production in rat spleen.
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