松果体及褪黑素经下丘脑对大鼠腹腔巨噬细胞化学发光的影响。
Effect of pineal body and melatonin on chemiluminescence of peritoneal macrophages via hypothalamus in rats.
作者信息
Wei W, Ding C H, Xu S Y
机构信息
Institute of Clinical Pharmacology, Anhui Medical University, Hefei, China.
出版信息
Zhongguo Yao Li Xue Bao. 1995 Sep;16(5):435-7.
AIM
To study whether the hypothalamus was a major relay for the action of melatonin (Mel) on peritoneal macrophage (PM subliminal diameter of) function.
METHODS
Pinealectomy, luminol-dependent chemiluminescence (CL), hypothalamic dinoprostone radioimmunoassay, and intrahypothalamic injection of Mel were done in rats kept under light:dark 12h:12h.
RESULTS
CL value of PM subliminal diameter of was decreased and hypothalamic dinoprostone content was elevated after pinealectomy, which were restored by Mel (10 micrograms kg-1 d-1 ip at 16:00 for 7 d). The same treatment of Mel increased CL value of PM subliminal diameter of and depressed hypothalamic dinoprostone production in intact rats. CL value of PM subliminal diameter of showed negative relation to hypothalamic dinoprostone with r = -0.78 (P < 0.01). Intrahypothalamic injection of Mel (2 micrograms) enhanced CL value of PM subliminal diameter of in normal and pinealectomized rats.
CONCLUSION
The hypothalamus is a main site of pineal Mel action upon PM subliminal diameter of function.
目的
研究下丘脑是否是褪黑素（Mel）作用于腹膜巨噬细胞（PM阈下直径）功能的主要中继站。
方法
对处于12小时光照：12小时黑暗条件下的大鼠进行松果体切除、鲁米诺依赖性化学发光（CL）、下丘脑地诺前列酮放射免疫测定以及下丘脑内注射Mel。
结果
松果体切除后，PM阈下直径的CL值降低，下丘脑地诺前列酮含量升高，Mel（10微克/千克体重，每天16:00腹腔注射，共7天）可使其恢复。相同的Mel处理可增加完整大鼠PM阈下直径的CL值并降低下丘脑地诺前列酮的产生。PM阈下直径的CL值与下丘脑地诺前列酮呈负相关，r = -0.78（P < 0.01）。下丘脑内注射Mel（2微克）可增强正常和松果体切除大鼠PM阈下直径的CL值。
结论
下丘脑是松果体Mel作用于PM阈下直径功能的主要部位。
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