Lu T, Vargas D, Franzblau S G, Fischer N H
Department of Chemistry, College of Basic Sciences, Louisiana State University, Baton Rouge 70803, USA.
Phytochemistry. 1995 Jan;38(2):451-6. doi: 10.1016/0031-9422(94)00625-4.
Investigation of the roots and aerial parts of Solidago rugosa afforded the known diterpenes kolavenol, hardwickiic acid, (-)-kaur-16-en-19-oic acid, (+)-manool, (+)-3 beta-hydroxymanool, manoyl oxide and ent-abietic acid. In addition, the new labdane diterpene (+)-18-tigloyloxymanool and four new ent-abietanes were obtained. The structures of all known and new compounds were elucidated by spectroscopic methods, especially high-field 1H and 13C NMR, and inverse 1H-13C-correlation techniques, as well as chemical transformations. Six diterpenes were tested against Mycobacterium tuberculosis and M. avium, but showed no significant activities with minimum inhibitory concentrations of > 100 micrograms ml-1.
对糙叶一枝黄花的根和地上部分进行研究，得到了已知的二萜类化合物柯拉文醇、哈德威克酸、（-）-贝壳杉-16-烯-19-酸、（+）-马尼醇、（+）-3β-羟基马尼醇、马尼酰氧化物和对映-枞酸。此外，还获得了新的半日花烷二萜（+）-18-惕各酰氧基马尼醇和四种新的对映-枞烷。所有已知和新化合物的结构均通过光谱方法进行了阐明，特别是高场1H和13C NMR以及反式1H-13C相关技术，以及化学转化。对六种二萜类化合物进行了抗结核分枝杆菌和鸟分枝杆菌的测试，但在最低抑菌浓度>100微克/毫升时未显示出显著活性。
