Altomonte L, Zoli A, Galossi A, Mirone L, Tulli A, Martone F R, Morini P, Laraia P, Magarò M
Institute of Internal Medicine and Geriatrics, Catholic University of the Sacred Heart, Rome, Italy.
Clin Exp Rheumatol. 1995 Jan-Feb;13(1):83-6.
Microvascular circulation was investigated by nailfold capillaroscopy in 32 patients affected by rheumatoid arthritis (RA). In all the patients elongated and tiny capillaries as well as tortuousity were the main shape abnormalities of the capillary loops. Higher subpapilar venous plexus (SPVP) visibility was evidentiated in patients presenting antinuclear and anti-RANA antibodies. No differences in the capillaroscopic pattern were found between rheumatoid factor positive and rheumatoid factor negative patients. In conclusion, elongated and tortuous capillaries seem to be the main alterations in RA, although they are not specific to the disease and are not correlated with the presence of rheumatoid factor. Higher SPVP visibility may be an expression of the endothelial damage induced by antinuclear antibodies in vessel walls.
通过甲襞毛细血管镜检查对32例类风湿性关节炎（RA）患者的微血管循环进行了研究。在所有患者中，毛细血管袢的主要形态异常为毛细血管细长且细小以及迂曲。在出现抗核抗体和抗RANA抗体的患者中，可见较高的乳头下静脉丛（SPVP）。类风湿因子阳性和类风湿因子阴性患者之间的毛细血管镜检查模式未发现差异。总之，虽然细长和迂曲的毛细血管并非RA所特有，也与类风湿因子的存在无关，但它们似乎是RA的主要改变。较高的SPVP可见度可能是血管壁中抗核抗体诱导的内皮损伤的一种表现。
