Zhao J, Niu R
Respiratory Disease Research Department Tongji Hospital, Wuhan.
Chin Med J (Engl). 1995 Feb;108(2):90-4.
In this study the effect of Sheng-Mai Injection i.e. Red Ginseng-Ophiopogon Root Injection (one kind of traditional Chinese medicines) on the contractivity of diaphragm was observed. The results confirmed that Sheng-Mai Injection increased Pdi of the fatigued diaphragm in rabbits and reduced the time needed for the recovery of Pdi of fatigued diaphragm to the normal value. These results suggest that Sheng-Mai Injection can increase the contractive force and promote the recovery of the fatigued diaphragm. The effect of Sheng-Mai Injection on the contractivity of the isolated diaphragmatic bundle of rats was also observed and the results confirmed that Sheng-Mai Injection increased the diaphragmatic contractive force directly. This effect of increasing the contractive force of diaphragm was attenuated by adding calcium channel blocker isoptin and disappeared when there was no calcium in the extracellular fluid. It is deduced, therefore, that the mechanism of the effect of Sheng-mai Injection is related to the increased influx of calcium from extracellular fluid into the cells.
本研究观察了生脉注射液即红参麦冬注射液（一种中药）对膈肌收缩性的影响。结果证实，生脉注射液可增加家兔疲劳膈肌的膈肌压力产生率（Pdi），并缩短疲劳膈肌Pdi恢复至正常水平所需的时间。这些结果表明，生脉注射液可增强收缩力并促进疲劳膈肌的恢复。还观察了生脉注射液对大鼠离体膈束收缩性的影响，结果证实生脉注射液可直接增强膈肌收缩力。添加钙通道阻滞剂异搏定后，这种增强膈肌收缩力的作用减弱，而细胞外液中无钙时该作用消失。因此推断，生脉注射液作用的机制与细胞外液钙内流增加有关。
